The spectroscopic characterisation of proline derivatives of tolyl-porphyrins and their iron and cobalt complexes

The new tolylporphyrin-prolin derivatives: TTP–CONH–Pro–COOCH2C6H5 and TTP–NHCO–Pro–Cbz and their iron and cobalt complexes have been synthesised and characterised by MS, IR, UV–vis, EPR and LIOAS spectroscopy studies. The EPR investigations demonstrate that Fe(III) and Co(II) ions are located in the site of distorted axial symmetry. Besides, for ferric porphyrins a thermally induced spin crossover was observed. The possibility of the applications in photodynamic therapy or diagnostics of cancerous tissues of the porphyrins obtained was studied. In the light of the experiments performed, from the group of investigated compounds, it seems that the metal-free TTP–NHCO–Pro–Cbz is well suited for PDT.