Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1405019 | Journal of Molecular Structure | 2014 | 8 Pages |
•36 co-crystallizations on compounds with two different acceptors were performed.•An interaction hierarchy was established using calculated electrostatic potentials.•All 10 structures obtained display best donor/acceptor halogen bonds.•Halogen bonds with iodine are more effective than the bromo-analogues.
A series of co-crystallization experiments were performed using four multi-topic N-heterocyclic acceptor molecules and nine aromatic halogen-bond donors in order to establish how effectively a ranking of bond strength based on calculated molecular electrostatic potential surfaces translates into predictable primary interactions in the solid state. A total of ten new crystal structures were obtained, and in each case, the observed interaction took place between the best acceptor (with the larger negative electrostatic potential) on the N-heterocycle and the halogen-bond donor. The supramolecular yield (number of successful co-crystallizations) is 70% for iodine-donors whereas none of the bromo-substituted donors produced a co-crystal which underscores the importance of the magnitude of the electrostatic potential and of the polarizability of the halogen-bond donor in the context of successful practical crystal engineering.