Assignment of NMR data and relative stereochemistry determination of paraconic acid derivatives

•The four paraconic acid derivatives had their structures fully elucidated.•A complete 1H and 13C NMR structural assignment was realized.•NOEDIFF experiments were used to determine the relative stereochemistry.

γ-Butyrolactones 4a1, 4a2, 4b1 and 4b2 were carefully studied through NMR experiments. 1H NMR, 13C {1H} NMR, COSY, HMQC, HMBC and J-res experiments were performed to provide the needed structure information. NOE between protons distributed around the stereocenters were thus used to determine the relative configuration of the molecules.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide