Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1405315 | Journal of Molecular Structure | 2015 | 10 Pages |
•Compounds synthesized for the first time.•And show antitumor activity.•The effective dose is 100 μM.
2,2-Dichloro-4,4,6,6-bis[spiro(2′,2″-dioxy-1′,1″-biphenylyl]cyclotriphosphazene (2) was synthesized from hexachlorocyclotriphosphazene (HCCP) and 2,2′-dihydroxybiphenyl. The mixed substituent chalcone/dioxybiphenyl cyclophosphazenes (2a–h) were obtained from the reactions of (2) with hydroxy chalcone compounds in K2CO3/acetone system. The chalcone-cyclophosphazene compounds were characterized by elemental analysis, FT-IR, 1H, 13C, 31P NMR techniques. In vitro anti-carcinogenic activities of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Anti-carcinogenic activity of the compounds (2a–h) against androgen-dependent (LNCaP) and independent (PC-3) human prostate cancer cell lines were investigated. Our results indicate that the chalcone-phosphazene compounds (2a–h) have anti-carcinogenic activity on PC-3 and LNCaP cell lines (p < 0.05). The effective dose of the compounds was determined as 100 μM.
Graphical abstractThe chalcone-cyclophosphazene compounds containing dioxybiphenyl groups (2a–2h) were synthesized. In vitro anti-carcinogenic activities of these compounds were performed by using MTT assay against PC-3 and LNCaP cancer cell lines. Results, these compounds (2a–2h) were found to have anti-tumor activity against PC-3 and LNCaP cancer cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide