Synthesis, characterization and anticancer evaluation of novel tri-arm star shaped 1,3,5-triazine hydrazones

A series of novel trisubstituted triazine hydrazones [N3C3(OC6H4-p-CHNNHC(O)C6H4-p-X)3] (X = H, Br, Cl, F, OH, OCH3, CH3, NO2, NH2) were prepared by a three-fold condensation reaction of 2,4,6-tris(4-formylphenoxy)-1,3,5-triazine with p-substituted benzoic acid hydrazides [NH2NHC(O)C6H4-p-X] with excellent yields. The structures were confirmed by elemental analysis, FT-IR, 1H, 13C, 2D-HSQC NMR and mass spectrometry (MALDI-TOF). These derivatives bearing hydrolysable hydrazone linkages were evaluated for their invitro antiproliferative activity against the human liver carcinoma cell line (HepG2) and human cervix carcinoma cell line (HeLa).

► Novel trisubstituted 1,3,5-triazine hydrazones synthesized. ► Structures of 1,3,5-triazine hydrazones are confirmed by spectroscopic techniques. ►In vitro antiproliferative activity was tested against HepG2 and HeLa cell lines.