Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1405878 | Journal of Molecular Structure | 2013 | 10 Pages |
•Synthesis of tetranuclear Cu(II) octaazamacrocycle complexes with aliphatic dicarboxylates.•Glutaric, adipic and sebacic acids as bridged co-ligands.•Analytical, spectral, magnetic and physico-chemical characterisation of Cu(II) complexes.•Antibacterial and cytotoxic activity of the complexes is found, in vitro.
New cationic Cu(II) complexes with N, N′, N″, N″′-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: pentanedioic (glutaric acid = glutH2), hexanedioic acid (adipic acid = adipH2) and decanedioic acid (sebacic acid = sebH2) of general formula [Cu4(L)(tpmc)2](ClO4)6·xH2O, L = glut, x = 2; L = adip, x = 7; L = seb, x = 6 were isolated. Their composition and charges are proposed based on elemental analyses and molar conductivity measurements. By the comparison of their UV–Vis, reflectance, FTIR and EPR spectral data, CV and SQUID magnetic measurements, with those for the complex with butanedioic acid (succinic acid = succH2) of known molecular structure and analysis of LC/MS spectra, geometry with two [Cu2tpmc]4+ units bridged by dicarboxylate dianion engaging all oxygens is proposed. Within units, Cu(II) ions are also bridged with N portion of cyclam ring. All four complexes were screened to in vitro antimicrobial and cytotoxic activity along with free primary and secondary ligands, Cu(II) salt and solvent controls. Detected antibacterial and cytotoxic activity for the complexes was enhanced in most cases than the corresponding controls.