| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1406996 | Journal of Molecular Structure | 2008 | 4 Pages |
Abstract
The in vitro metabolism of swertiamarin was carried out in preparative scale using the fungus Aspergillus niger and the metabolites were isolated by semi-preparative HPLC combined with liquid-liquid extraction. Two metabolites, erythrocentaurin and one new compound were obtained and identified by 1H, 13C and 2D NMR and high resolution MS. The anti-inflammatory activity of the novel metabolite was tested and compared with that of swertiamarin in a mice model.
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Authors
Chang Jun, Zhao Xue-Ming, Liu Chang-Xiao, Zhang Tie-Jun,