Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1407078 | Journal of Molecular Structure | 2008 | 10 Pages |
Abstract
The crystal structures of antimalarial drug amodiaquine in the form of its free base and two salts, dihydrochloride monohydrate and tetrachlorocobaltate(II), were determined with X-ray single crystal diffractometry. Their conformations and intermolecular interactions are compared to those found in the crystalline amodiaquine dihydrochloride, postulated to contain hydroxyl anion, and in the powder amodiaquine dihydrate dihydrochloride. The molecular structures of the amodiaquine cation and its free base were optimized by the B3LYP calculations and compared to those observed in the crystalline state.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Agata Semeniuk, Agnieszka Niedospial, Justyna Kalinowska-Tluscik, Wojciech Nitek, Barbara J. Oleksyn,