Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1408046 | Journal of Molecular Structure | 2015 | 12 Pages |
Abstract
Six new 3(5)-trifluoromethyl-5(3)-substituted-styryl-1H-pyrazoles have been synthesized and their tautomerism studied in solution and in the solid state. The determination of their structures has been based on multinuclear NMR spectroscopy together with GIAO/B3LYP/6-311++G(d,p) theoretical calculations of eight structures for each pyrazole (two tautomers and four conformations). Five out of the six compounds present inhibition percentages of the iNOS isoform higher than 50%. With regard to the nNOS inhibitory activity, only two of the studied compounds show an inhibition of about 50%. Finally, concerning the eNOS, there is a compound presenting a low percentage of inhibition (40.2%) attaining in the other cases 50%.
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Authors
Carla I. Nieto, M. Pilar Cabildo, M. Pilar Cornago, Dionisia Sanz, Rosa M. Claramunt, Ibon Alkorta, José Elguero, José A. GarcÃa, Ana López, DarÃo Acuña-Castroviejo,