Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1408188 | Journal of Molecular Structure | 2006 | 8 Pages |
Abstract
Hydrochlorothiazide was characterized in order to determine the possible structural modifications at different temperatures due to its importance as a drug to control heart diseases and a diuretic. This compound could present conformers due to the rotation of the NH2 group, which was studied by using different techniques such as Thermal Analysis, IR spectroscopy, X-Ray Diffraction and complemented by theoretical calculations. The theoretical and experimental results point to the conclusion that no polymorphic forms are present in the compound under study. The calculations confirm the apparent difference in values between theory and experiment for the vibration frequencies explained by the hydrogen bonds between near molecules.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Juan M. Aceves-Hernández, Esther Agacino-Valdés, Manuel Paz, Jaime Hinojosa-Torres,