| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1408291 | Journal of Molecular Structure | 2006 | 5 Pages |
Abstract
The present work is aimed to investigate non-covalent bonding capabilities of uracil derivative bearing hydrophobic side chain in solid crystalline state. The synthesis and crystal structure of 5-(2-chloro-ethyl)-6-methyl-uracil 3 and 5-(2-chloro-ethyl)-6-methyl-2-thiouracil 4 are described, which revealed sulfur-Ï interaction including resonance-induced intermolecular H-bonding in 4 whereas compound 3 showed only strong H-bonding and formed a dimer. Thus the analysis of such moieties in solid state provides useful structural information on the binding characteristics of functional groups and has implications for the de novo design of drugs and enzyme's inhibitors.
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Authors
Fateh V. Singh, Rishi Kumar, Ashoke Sharon, Charlotte K. Broder, Judith A.K. Howard, Atul Goel, Prakas R. Maulik,