Stereoselective synthesis, spectral and antimicrobial studies of some cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones

•Stereoselective synthesis of some cyanoacetyl hydrazones.•Characterization through IR, Mass, 1H NMR, 13C NMR and 2D NMR spectral techniques.•Establishment of stereochemistry through NMR spectra.•In-vitro evaluation of antibacterial and antifungal potencies.

A series of novel cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones were synthesized stereoselectively and characterized by IR, Mass, 1H NMR, 13C NMR, 1H–1H COSY and 1H–13C COSY spectra. The stereochemistry of the synthesized compounds was established using NMR spectra. Antimicrobial screening of the synthesized compounds revealed their antibacterial and antifungal potencies. Growth inhibition of Enterobacter Aerogenes by compound 15 was found to be superior to the standard drug.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide