Synthesis, structure, optical properties, antifungal and antibacterial activities of 2-(1-oxo-1H-2,3-dihydroisoindol-2-yl)-3-imidazolyl-L-lactamic acid

•This paper described the preparation and full characterization of a new phthalimidin derivative.•The compound exhibits blue–green emission with peaks at 354.5 and 486.5 nm.•Second harmonic generation (SHG) property was investigated at the first time for this kind of compound.•The compound has moderate antibacterial and antifungi activities.

2-(1-oxo-1H-2,3-dihydroisoindol-2-yl)-3-imidazolyl-L-lactamic acid has been prepared conveniently by the condensation reaction of o-phthalaldehyde (OPA) with L-Histidine, and its single crystal structure has been characterized by X-ray crystallography method. The in vitro antifungal and antibacterial activities of the compound were investigated with the representative strains of Candida albicans, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Its luminescent and nonlinear optical properties have also been investigated. Second-harmonic-generation (SHG) measurements indicate that compound 1 displays a weak SHG response of about 0.75 times that of KH2PO4.

Graphical abstractThis paper describes the preparation and full characterization of versatile Phthalimidin derivative 2-(1-oxo-1H-2,3-dihydroisoindol-2-yl)-3-imidazolyl-L-lactamic acid with antibacterial and antifungi activity, blue-green fluorescent emission and second-harmonic generation (SHG) properties.Figure optionsDownload full-size imageDownload as PowerPoint slide