| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1408825 | Journal of Molecular Structure | 2016 | 10 Pages |
•2-methoxy-6-(2-morpholinoethyliminomethyl)phenol (HL) explored as sensor for Zn2+.•The emission intensity of HL enhanced ∼ 25 times in the presence of one eqv. of Zn2+.•Limit of detection of HL for Zn2+ determined as low as 40.5 nM.•Formed 1:1 complex with Zn2+ and confirmed by X-ray single crystal diffraction study.•Used for imaging of DLD-1, human colorectal adenocarcinoma cell.
The selective fluorescence zinc(II) sensing properties of a Schiff-base compound, 2-methoxy-6-(2-morpholinoethyliminomethyl)phenol (HL) have been explored. The emission intensity of HL in the presence of one equivalent of Zn2+ ion increases by about 25 times. Several other metal ions, except Cd2+ and Ni2+, have not been able to increase the emission intensity of HL significantly. The quantum yield and life-time of HL have also been increased in the presence of Zn2+ ions. The enhancement in fluorescence intensity of HL is mainly due to the restriction of ESIPT, CHEF and PET on complex formation. HL forms a complex with Zn2+ in 1:1 ratio as evidenced by Job's plot analysis and X-ray single crystal structure determination. Some theoretical calculations have been performed to get a better view on the nature of the observed electronic transitions. The probe has been applied for imaging of DLD-1, human colorectal adenocarcinoma cell.
