Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1409199 | Journal of Molecular Structure | 2015 | 6 Pages |
Abstract
An exciting isatin-thiazoline hybrid molecule 2 having -CN-NC- linkage has been synthesized in 88% yield by the reaction of 5-fluoroisatin with N-(4-fluorophenyl)hydrazinecarbothioamide followed by condensation of the resultant isatin-thiosemicarbazone intermediate with p-chlorophenacyl bromide. The solid state self-assembly of this hybrid molecule was studied by X-ray crystallographic technique. A layered assembly composed of 1D-chains with methanol molecules encapsulated between every two chains is obtained, making a bi-chain sandwich like structure. The supramolecular forces involved in the stabilization of this structure are importantly fluorine-mediated interactions (C-Hâ¯F, Fâ¯S and Fâ¯Ï) along with others i.e. N-Hâ¯O, O-Hâ¯O, C-Hâ¯O, Clâ¯Ï, C-Hâ¯Ï and Ïâ¯Ï interactions. To the best of our knowledge, this is the first example of solid state fluorine-mediated C-Hâ¯F, Fâ¯S and Fâ¯Ï interactions found in a family of isatin-based compounds.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Humayun Pervez, Maqbool Ahmad, Taibi B. Hadda, Loic Toupet, Muhammad Moazzam Naseer,