Ionic liquid catalyzed one-pot multi-component synthesis, characterization and antibacterial activity of novel chromeno[2,3-d]pyrimidin-8-amine derivatives

An efficient, simple and convenient method for the one-pot multi-component synthesis of novel chromeno[2,3-d]pyrimidin-8-amine derivatives has been accomplished by starting from α-naphthol, aryl aldehydes, malononitrile and NH4Cl. The reaction has been catalyzed by 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4 ionic liquid. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass spectra, and elemental analysis. The structure of compound 4a was confirmed by single-crystal X-ray diffraction. All the synthesized compounds were evaluated for their in vitro antibacterial activity.

► Chromenopyrimidines were synthesized with an aid of ionic liquid catalyst. ► Synthesized compounds were characterized by elemental analysis and spectroscopy. ► Compound 4a was confirmed by single crystal X-ray diffraction. ► Amino (NH2) group has not involved in any hydrogen bonding. ► Synthesized compounds were evaluated for their in vitro antibacterial activity.