Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1411306 | Journal of Molecular Structure | 2009 | 6 Pages |
Abstract
Spontaneous resolution of cardioselective β1-adrenergic blocker bevantolol hydrochloride1·HCl was established by IR spectroscopy, differential scanning calorimetry, and by single crystal X-ray analysis both for enantiopure and racemic samples. The absolute configuration of 1·HCl was evaluated through Flack parameter method. The molecular structure and crystal packing details were evaluated; the symmetry independent fragment of the P1 unit cell consists of two molecules which have almost identical spatial arrangement, but differ sufficiently in the nature of nitrogen atoms: quaternary form in one case and free amine form in the other.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zemfira A. Bredikhina, Dmitry V. Zakharychev, Aidar T. Gubaidullin, Alexander A. Bredikhin,