Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1411529 | Journal of Molecular Structure | 2009 | 5 Pages |
Abstract
C-6 substituted fluoroalkenyl 2,4-dimethoxypyrimidine derivative (4) was synthesized by lithiation of 2,4-dimethoxy-6-methylpyrimidine (3) and subsequent reaction of thus obtained organolithium intermediate with ethyl pentafluoropropionate. The novel 2,4-pyrimidinedione containing 3,3,4,4,4-pentafluoro-1-butenyl side chain (5) was prepared by demethoxylation of 4 using sodium iodide and chlorotrimethylsilane. The structures of 4 and 5 were confirmed by 1H, 13C and 19F NMR spectra, as well as IR spectra. The structure of 4 was also unambiguously confirmed by X-ray crystal structure analysis. The molecules of 4 are weakly linked by aromatic ÏÂ·Â·Â·Ï stacking interactions into infinite chains parallel to the a axis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Svjetlana KriÅ¡tafor, Tatjana Gazivoda, Mario Cetina, Damjan Makuc, Janez Plavec, Silvana RaiÄ-MaliÄ,