Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1411596 | Journal of Molecular Structure | 2009 | 9 Pages |
Abstract
A novel ligand idpq with embedded CO and its two complexes, [Ru(bpy)2(idpq)]2+1 and [Ru(phen)2(idpq)]2+2 (bpy = 2,2â²-bipyridine; phen = 1,10-phenanthroline; idpq = indeno[1,2-b]dipyrido [3,2-f:2â²,3â²-h]-quinoxaline-6-one), have been synthesized and characterized by elemental analysis, ES-MS, 1H NMR, UV-vis and CV. The DNA-binding behaviors of both complexes were studied by spectroscopic methods and viscosity measurements. The results indicate that the two complexes can all bind to CT-DNA in an intercalative mode, and they have rather high DNA-binding constants, which are (1.7 ± 0.4) Ã 106 Mâ1 and (4.0 ± 0.6) Ã 106 Mâ1, respectively. The results also show that these two Ru(II) complexes can promote photocleavage of pBR322 DNA. Their DNA-binding and electronic absorption-spectral properties were further studied by the DFT/TDDFT methods. The DNA-binding behaviors and difference of these complexes were reasonably explained, and the simulated absorption spectra were in good agreement with the experimental ones.
Keywords
TDDFTdpqdppzFAB-MSbpyMLCTDNA-photocleavageTRISPPDESI-MS1,10-Phenanthroline2,2-BipyridineCt-DNADFTCalf thymus DNADNA-bindingEDTAEthylenediaminetetraacetic acidMetal-to-ligand charge transferTris(hydroxymethyl)aminomethane hydrochloridecircular dichroismElectronic absorption spectraelectrospray ionisation mass spectrometryPhenRu(II) complexDFT calculationDensity functional theoryTime-dependent density functional theoryCyclic voltammetryPiP
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xue-Wen Liu, Lian-Cai Xu, Hong Li, Hui Chao, Kang-Cheng Zheng, Liang-Nian Ji,