| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 14246 | Biotechnology Advances | 2014 | 11 Pages |
Abstract
The review presents the state-of-the-art in the applications of in-situ product recovery (ISPR) in whole-cell biotechnology over the last 10 years. It summarizes various ISPR-integrated fermentation processes for the production of a wide spectrum of bio-based products. A critical assessment of the performance of various ISPR concepts with respect to the degree of product enrichment, improved productivity, reduced process flows and increased yields is provided. Requirements to allow a successful industrial implementation of ISPR are also discussed. Finally, supporting technologies such as online monitoring, mathematical modeling and use of recombinant microorganisms with ISPR are presented.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Wouter Van Hecke, Guneet Kaur, Heleen De Wever,