| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 14278 | Biotechnology Advances | 2014 | 9 Pages |
Abstract
RNAi-based nucleic acid molecules have attracted considerable attention as compelling therapeutics providing safe and competent delivery systems are available. Dendrimers are emerging as appealing nanocarriers for nucleic acid delivery thanks to their unique well-defined architecture and the resulting cooperativity and multivalency confined within a nanostructure. The present review offers a brief overview of the structurally flexible triethanolamine-core poly(amidoamine) (PAMAM) dendrimers developed in our group as nanovectors for the delivery of RNAi therapeutics. Their excellent activity for delivering different RNAi therapeutics in various disease models in vitro and in vivo will be highlighted here.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Xiaoxuan Liu, Cheng Liu, Carlo V. Catapano, Ling Peng, Jiehua Zhou, Palma Rocchi,