Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
14358 | Biotechnology Advances | 2013 | 6 Pages |
Abstract
Both prokaryotes and eukaryotes have pyramid-shaped hierarchical regulatory networks that control gene transcription, enabling the cell to respond to natural environmental changes. In recent years, manipulation and engineering of transcriptional regulatory proteins and networks have been used to elicit microbial tolerance to industrially relevant stresses. We review the current research on the engineering of regulators that include specific, “middle level”, and global regulators, and native, artificial, and exogenous regulators. With an increasing number of transcriptional regulators identified and characterized, this methodology should prove promising for the improvement of microbial stress tolerance.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Zhanglin Lin, Yan Zhang, Jianqing Wang,