Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
15394 | Computational Biology and Chemistry | 2008 | 4 Pages |
Abstract
Microtubules perform a variety of functions which lead to the complex regulation of intracellular transport and cell division. However, the regulation of microtubule growth is not clearly known. Based on a recent experimental finding, we explore the possibility of spatial regulation of microtubule growth by stathmin–tubulin interaction gradients. Computer simulation of the model with stathmin–tubulin interaction gradients gave regulated growth as seen in experiments. In future, the stathmin–tubulin interaction gradients can be made dynamic and its impact on the microtubule growth can be explored.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Kh. Budhachandra, R.K. Brojen Singh, G.I. Menon,