| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 15653 | Current Opinion in Biotechnology | 2013 | 7 Pages |
Site isolation, compartmentalization and substrate specificity are a few of the characteristics responsible for the catalytic efficiency demonstrated by enzymes in natural systems. In efforts to mimic these highly efficient systems, research has been directed towards macromolecular chemistry. Robust polymer assemblies can create a favorable and isolated environment around the catalytic site allowing specific and sometimes incompatible reactions to take place within this protected reaction pocket. Further exploring the use of ‘smart’ polymers, control over both the catalytic activity and substrate specificity is achieved. In addition, polymeric systems provide the opportunity for recycling of the active catalysts, further enhancing the advantages of polymer supported catalytic systems.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (197 K)Download as PowerPoint slideHighlights► Functional polymer nanostructures as efficient supports for confined catalysis. ► Polymer scaffold can provide protection of active catalyst for prolonged activity. ► Hydrophobic cavities allows for efficient organic reactions to take place in water. ► Stimuli-responsive polymers can provide control over nanoreactor catalytic activity. ► Folding of single polymer chains show potential for future enzyme mimic systems.
