Mechanical factors in embryonic tendon development: potential cues for stem cell tenogenesis

•Mechanical influences on tendon cells during embryonic development are reviewed.•Potential mechanisms of mechanotransduction in embryonic tendon cells are discussed.•Mechanoregulation strategies to induce tenogenesis of stem cells are examined.

Tendons are connective tissues required for motion and are frequently injured. Poor healing and inadequate return to normal tissue structure and mechanical function make tendon a prime candidate for tissue engineering; however functional tendons have yet to be engineered. The physical environment, from substrate stiffness to dynamic mechanical loading, may regulate tenogenic stem cell differentiation. Tissue stiffness and loading parameters derived from embryonic development may enhance tenogenic stem cell differentiation and tendon tissue formation. We highlight the current understanding of the mechanical environment experienced by embryonic tendons and how progenitor cells may sense and respond to physical inputs. We further discuss how mechanical factors have only recently been used to induce tenogenic fate in stem cells.

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