Are deformed neurons electrophysiologically altered? A simulation study

The electrophysiological outcome of neuron deformation is studied. This study is based on modeling the propagation of action potentials in a neuron with different deformed segments subject to an external mechanical compression. The proposed model is based on modified cable equation incorporating geometry variations. The study is performed for different degrees and number of deformations of the axon structure. The results of simulation show that the propagation speed, the refractory period, and the action potential broadening are all directly affected by variations in the geometry.