| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 178866 | Electrochemistry Communications | 2015 | 4 Pages |
•Multiple kinds of target cells can be detected simultaneously by coupling logic operation design.•The array results can be easily obtained by a layman via a digital multimeter at home or in the field.•Micron-level Au lines can effectively reduce the nonspecific absorption and improve the sensitivity of detection.•This chip is small in size and can be produced in mass production with low cost.
A logic aptamer sensor platform was developed for intelligent detection of two types of cancer cells based on the interdigital Au-line microarray (IAuLM) chip. The signal of resistance change caused by capturing of target cells with the aptamers modified on IAuLM is easy to be measured with a commercially available multimeter. By coupling logic operation design, the intelligent diagnostics for multiple kinds of cancer cells could be made. Target cells in blood samples were successfully detected by this chip, indicating that this method can be employed for the early diagnose of cancer and holds promising potential in point of care testing and clinical applications.
Graphical abstractA novel method, in which a commercially available multimeter is used to measure the signal of resistance change caused by capture of target cells with the aptamers modified on interdigital Au-line microarray to perform logic-based analysis of multiple kinds of cancer cells, is developed for the first time based on microfluidic chip.Figure optionsDownload full-size imageDownload as PowerPoint slide
