| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 178901 | Electrochemistry Communications | 2015 | 5 Pages |
•Conversion of GSH to GSSG by electrogenerated ROS was highlighted.•Two reaction pathways for the GSH reaction depending upon [GSH] were characterized.•Role of the presence of dissolved oxygen in trace level was identified.•Presence of higher dissolved oxygen affects the sensitivity of GSH determination.•Determination of ‘total GSH’ by electro-reduction of GSSG on Au was achieved.
The thiol to disulfide inter-conversion plays vital role in the glutathione (GSH) metabolism in human body. Mimicking the GSH conversion to disulfide by electro-generated reactive oxygen species at gold electrode interface and the use of electro-reduction of the produced disulfides for the electro-analysis of low levels of GSH is reported.
Graphical abstractThe thiol to disulfide inter-conversion plays vital role in the glutathione (GSH) metabolism in human body. Mimicking the GSH conversion to disulfide by electro-generated reactive oxygen species at gold electrode interface and the use of electro-reduction of the produced disulfides for the electro-analysis of low levels of GSH is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
