New stochastic microsensors based on oleamides

•New stochastic microsensors based on graphite paste were designed.•Six oleamides were used as modifiers for graphite paste.•Carcinoembryonic antigen was used as model analyte.•High reliabilities and sensitivities were recorded for the new microsensors.

Six oleamides: oleoylethanolamide, (Z)-N-[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]-9octadecenamide, N-phenethyloleamide, N-[2-(4-methoxyphenyl)ethyl]oleamide, N-[1]naphthyloleamide, N-cyclohexyloleamide were synthesized and used as modifiers for the design of new stochastic microsensors based on graphite paste. Carcinoembryonic antigen (CEA) was used as a model analyte to prove the stochastic behavior of the microsensors. CEA was determined directly from whole blood samples with recoveries higher than 94.00%, favorizing pattern recognition of CEA in whole blood samples. The most sensitive stochastic microsensor was the one based on the physical immobilization of N-[2-(4-methoxyphenyl)ethyl]oleamide in graphite paste.