| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 180316 | Electrochemistry Communications | 2011 | 4 Pages |
A novel genosensor platform based on supramolecular interactions has been developed based on the self-assembly of bifunctionalised polymer bearing adamantane and DNA onto cyclodextrin surfaces. The surface chemistry can undergo a controlled regeneration, as revealed by SPR and impedance spectroscopy, has an excellent detection limit of 0.08 nM and demonstrated high selectivity, clearly differentiating between complementary and non-complementary DNA sequences. The performance of the developed genosensor was validated by applying it to the detection of DNA in a real patient sample that had been previously genotyped.
Graphical AbstractFigure optionsDownload full-size imageDownload as PowerPoint slideResearch Highlights►Interfacial self-assembly of adamantane-cyclodextrin pairs to modify surfaces. ►Electrochemical DNA detection using supramolecular surface sensitive and selective. ►Supramolecular genosensor performance validated in genotyped patient sample.
