Measuring water content using T2 relaxation at 3Â T: Phantom validations and simulations

This work demonstrates that, using the T2 relaxation decay curve, TWC can be measured to within 3% accuracy at 3 T. Given that T2 relaxation can provide accurate estimates of both TWC and myelin water fraction, multi-echo T2 measurement should be considered a multifaceted approach for assessing pathology and evaluating therapy of central nervous system diseases.