Cerebral blood flow estimation from perfusion-weighted MRI using FT-based MMSE filtering method

For low-noise condition, the FT-based technique was more stable than the SVD technique, while for moderate noise, both techniques consistently underestimated CBF. SVD technique was found to be more stable in presence of AIF distortions. However, SVD technique was found to be unstable due to AIF delay compared to the FT-based MMSE method. The shaped filter function was found to be sensitive to effect of AIF distortions.