Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1807711 | Magnetic Resonance Imaging | 2010 | 9 Pages |
Abstract
A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (μg Fe/gwet tissue)=(6.4±0.4)·R2* septum (sâ1) â (120±40). The results demonstrated that septal R2* indeed measures cardiac iron level.
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Authors
Zhiyue J. Wang, Roland Fischer, Zili Chu, Donald H. Jr., Brigitta U. Mueller, Raja Muthupillai, Ellen B. James, Rajesh Krishnamurthy, Taylor Chung, Eric Padua, Elliott Vichinsky, Paul Harmatz,