Article ID Journal Published Year Pages File Type
1807928 Magnetic Resonance Imaging 2009 10 Pages PDF
Abstract

PurposeTo evaluate the apparent diffusion coefficient (ADC) of skeletal muscle based on signal intensity (SI) attenuation vs. increasing b values and to determine ADC differences in skeletal muscles between genders, age groups and muscles.Materials and MethodsDiffusion-weighted images (b values in the range of 0–750 s/mm2 at increments of 50 s/mm2) of the ankle dorsiflexors (116 subjects) and the erector spinae muscles (86 subjects) were acquired with a 1.5-T MR device. From the two different slopes obtained in SI vs. b-value logarithmic plots, ADCb0–50 (b values=0 and 50 s/mm2) reflected diffusion and perfusion, while ADCb50–750 (b values in the range of 50–750 s/mm2 at increments of 50 s/mm2) approximated the true diffusion coefficient. Moreover, to evaluate whether this b-value combination is appropriate for assessing the flow component within muscles, diffusion-weighted images of the ankle dorsiflexors (10 subjects) were obtained before and during temporal arterial occlusion.ResultsADCb0–50 and ADCb50–750 were found to be 2.64×10–3 and 1.44×10–3 mm2/s in the ankle dorsiflexors, and 3.02×10–3 and 1.49×10–3 mm2/s in the erector spinae muscles, respectively. ADCb0–50 was significantly higher than ADCb50–750 in each muscle (P<.01). The erector spinae muscles showed significantly higher ADC values than the ankle dorsiflexors (P<.01). However, for each muscle, there were few significant gender- and age-related ADC differences. Following temporal occlusion, ADCb0–50 of the ankle dorsiflexors decreased significantly from 2.49 to 1.6×10–3 mm2/s (P<.01); however, ADCb50–750 showed no significant change.ConclusionBased on the SI attenuation pattern, muscle ADC could be divided into ADC that reflects both diffusion and perfusion, and ADC that approximates a true diffusion coefficient. There were significant differences in ADC of functionally distinct muscles. However, we barely found any gender- or age-related ADC differences for each muscle.

Related Topics
Physical Sciences and Engineering Physics and Astronomy Condensed Matter Physics
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