Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1808101 | Magnetic Resonance Imaging | 2006 | 5 Pages |
Abstract
The main findings related statistically significant decreases in the mean metabolite ratios for NAA/Cr, NAA/Cho and Cho/Cr in the anterior parts in comparison with the posterior parts of the centrum semiovale in symptomatic and asymptomatic patients. The effect was considerably greater in the symptomatic patients, indicating a strong correlation between CSI and pathology results. No differences were found between the two areas in the control group. Although lactate signals were hardly detectable in individual spectra, there was a trend toward increased Lac/Cr values in the anterior parts with respect to the posterior parts in the patient group, with the effect particularly evident in the asymptomatic subjects with the gene mutation.
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Authors
Maria Antonietta Macrì, Claudio Colonnese, Girolamo Garreffa, Francesco Fattapposta, Rita Restuccia, Federico Bianco, Ludovica Labruna, Bruno Maraviglia,