Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
18162 | Enzyme and Microbial Technology | 2007 | 5 Pages |
Abstract
Biological transformation of the bioactive sesquiterpene, cyclonerodiol (1), isolated from marine-derived fungus Myrothecium sp., was studied. Preparative-scale fermentation of 1 with marine-derived fungus Penicillium sp. resulted in the isolation of a new glycosidic metabolite, 7-O-(β-d-mannopyranosyl)cyclonerodiol (2). Fermentation of 1 for 2 weeks with a marine isolate of the actinomycete bacteria Streptomyces sp. also afforded two oxidized geometrical isomers, 10(Z)- and 10(E)-cyclonerotriols (3, 4). The stereostructure of the metabolites obtained was assigned on the basis of detailed spectroscopic data analyses and chemical reaction.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Xifeng Li, Young Hwa Kim, Jee H. Jung, Jung Sook Kang, Dong-Kyoo Kim, Hong Dae Choi, Byeng Wha Son,