Article ID Journal Published Year Pages File Type
18162 Enzyme and Microbial Technology 2007 5 Pages PDF
Abstract

Biological transformation of the bioactive sesquiterpene, cyclonerodiol (1), isolated from marine-derived fungus Myrothecium sp., was studied. Preparative-scale fermentation of 1 with marine-derived fungus Penicillium sp. resulted in the isolation of a new glycosidic metabolite, 7-O-(β-d-mannopyranosyl)cyclonerodiol (2). Fermentation of 1 for 2 weeks with a marine isolate of the actinomycete bacteria Streptomyces sp. also afforded two oxidized geometrical isomers, 10(Z)- and 10(E)-cyclonerotriols (3, 4). The stereostructure of the metabolites obtained was assigned on the basis of detailed spectroscopic data analyses and chemical reaction.

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Physical Sciences and Engineering Chemical Engineering Bioengineering
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