Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
181664 | Electrochemistry Communications | 2008 | 4 Pages |
Abstract
The ion-channel behavior of annexin V in phosphatidylcholine bilayer membranes (BLM) is studied from the peaks currents of Fe(CN)63-/4- and Ru(bpy)32+ which are used as electrochemical probes. It is demonstrated that annexin V can form pores in the lipid membrane that allow both Fe(CN)63-/4- and Ru(bpy)32+ probes to reach the surface of the substrate electrode. The influence of Ca2+, pH and protein concentration on the ion-channel formation is also examined. This may provide a simple and general way to study this important biological process.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Junyi Huang, Lin Chen, Xin Zhang, Shanli Liu, Genxi Li,