An electrochemical method to detect folate receptor positive tumor cells

This paper reports an electrochemical method to detect folate receptor positive tumor cells by making use of the interaction between folic acid immobilized on gold nanoparticles and its receptor over-expressed on tumor cell membrane. Experimental results have shown that a gold electrode modified with folic acid functionalized gold nanoparticles can clearly denote folate receptor positive tumor cells, such as ovarian tumor cells and human cervical cancer cells. So, electrochemical technique has been introduced for cancer cells detection and a simple method to detect folate receptor positive tumor cells has been developed.