Article ID Journal Published Year Pages File Type
18256 Enzyme and Microbial Technology 2007 7 Pages PDF
Abstract

Trichoderma hamatum KCh25 was used to study the mode of transformation of a series of 3-oxosteroids. This potential has not been previously examined. The strain promoted 1-dehydrogenation, which have been rarely observed in fungi cultures. The metabolism of cortexolone resulted in efficient conversion to 1-dehydrocortexolone, with no other product isolated. The other routes of biotransformations of the substrates included: hydroxylation at equatorial 11α, 6α, and 12β positions, ester bond hydrolysis, oxidation of 17α-hydroxyl group, C-17/C-20 bond scission, and the ring D-lactonization. The correlation between a steroid compound structure and the transformation profile and also succession of the observed reactions has been noticed.

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Physical Sciences and Engineering Chemical Engineering Bioengineering
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