| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1848359 | Nuclear Science and Techniques | 2006 | 5 Pages |
Abstract
The weight loss in vivo degradation of poly (lactide-co-glycolide) (PLGA) radiolabeled with 125I was investigated. PLGA with molecular weight (Mw) of 84000(LA/GA = 85/15) were labeled with 125I in the chloroform media by circularly heating and round films of about 15 mm in diameter were formed. The composition and Mw of the 125I-PLGA were characterized by 1H-NMR and viscosimeter. The weight loss of this copolymer in vitro and in vivo degradation was quantified by determining radioactivity of materials. The results indicated that PLGA exhibited significantly faster degradation in vivo than that of in vitro conditions.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Nuclear and High Energy Physics
Authors
Nan HUA, Jiao SUN,