Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1877147 | Applied Radiation and Isotopes | 2008 | 10 Pages |
Abstract
A high-yield radioiodination method for various types of molecules is described. The approach employs DMSO as precursor solvent, a reaction ratio of 2–5 precursor molecules per iodine atom, 5–10 μg oxidant, and a 10–25 μl reaction volume. The solution is vortexed at room temperature for 1–5 min and progress of the reaction is assessed by HPLC. Radioiodinated products are obtained in ≥95% yield and meet the requirements for radiotracer imaging, biodistribution studies, and molecular and cellular biology research.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Ketai Wang, S. James Adelstein, Amin I. Kassis,