| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1887453 | Radiation Physics and Chemistry | 2007 | 5 Pages |
Abstract
New liposome formulations for antimycobacterial purpose are under development in Portugal. The drug must be submitted to a sterilization process. In order to find out if gamma radiation could be applied, microbiological and chemical studies were developed based on ISO standards. The bioburden was determined, the main critical points of line production were detected and the sterilization dose was determined based on a chart control for bioburden. A preliminary maximum acceptable dose for product was found out based on the main functional parameters.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
M.L. Botelho, S. Cabo Verde, L. Alves, A. Belchior, J. Reymão, S. Trabulo, M.M. Gaspar, M.E.M Cruz, S. Simões,