Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1887737 | Radiation Physics and Chemistry | 2006 | 9 Pages |
Abstract
Hydrogels were synthesised using the photoinitiator-free photopolymerisation technique involving interactions between donor/acceptor pairs for delivering drugs of different molecular weights including a porphyrin used as a tumour-tracing agent. N-(5-hydroxy) pentylmaleimide, an acceptor, formed hydrogels with N-vinyl-2-pyrrolidinone, 2-hydroxyethyl methacrylate and N-vinylcaprolactum. Glucosamine, an effective H-donor in enhancing polymerisation as shown by Differential Photocalorimetric results, was found unsuitable for hydrogel preparation. Drugs of different molecular weights releasing at the same rate was discussed. The hydrogels were found to have no toxic effects and were biocompatible with a human keratinocyte cell line.
Related Topics
Physical Sciences and Engineering
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Radiation
Authors
Loo-Teck Ng, Salesh Swami, Clare Gordon-Thomson,