Equilibrium theory in 2D Riemann manifold for heterogeneous biomembranes with arbitrary variational modes

Based on the first and second gradient operators and their integral theorems in 2D Riemann manifold, the equilibrium differential equations and geometrically constraint equations for heterogeneous biomembranes with arbitrary variation modes are developed. Through the combination of these equations, the equilibrium theory for heterogeneous biomembranes is established in 2D Riemann manifold. From the equilibrium theory, various interesting information is revealed: Different from homogeneous biomembranes, heterogeneous one posses new equations within the membrane’s tangential planes, i.e. the in-plane equilibrium differential equations, the in-plane boundary conditions and the in-plane geometrically constraint equations. Different from the equilibrium theory in Euclidean space, the one in 2D Riemann manifold displays strict constraints between the physical coefficients and characteristic geometric parameters of biomembranes.