| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1906425 | Experimental Gerontology | 2011 | 10 Pages |
Abstract
âºChronic feeding of corn oil enriched diet develops obesity and subsequent adverse effect on skeletal health in aging mice. âºObesity-mediated chronic inflammation altered the bone marrow microenvironment. âºAge-associated bone marrow adiposity stimulates osteoclastogenesis in mice. âºAdipocyte-derived inflammatory cytokines promotes bone resorption and adversely impact on bone microarchitecture and osteoblast development.
Keywords
PPARBone marrow adiposityTNFOPGphorbol 12-myristate 13-acetateDXATRAPAINRT-PCRRANKLRUNX2BMCBV/TVVOIPMAROSAdipocytesOsteoprotegerininterleukinMicro-Computer Tomographydual energy X-ray absorptiometryvolume of interestCorn oilAgingSODBone marrow cellsSuperoxide dismutaseRunt-related transcription factor 2tumor necrosis factorObesitybone marrowAmerican Institute of NutritionMicro-CTreverse transcriptase polymerase chain reactionOsteoporosisVisceral fatReactive oxygen speciesperoxisome proliferators-activated receptor
Related Topics
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Ganesh V. Halade, Amina El Jamali, Paul J. Williams, Roberto J. Fajardo, Gabriel Fernandes,