Association of serum uric acid with body mass index among long-lived Chinese

ObjectivesTo examine the individual association between BMI and level of serum uric acid (SUA) among the very elderly Chinese population.MethodsA survey was conducted on 870 long-lived subjects (aged ≥ 90 years). Subjects were divided into four groups according to quartile of BMI (< 16.6, 16.6–18.9, 18.9–21.1, ≥ 21.1 kg/m2) and to classification criteria of underweight, normal weight, overweight and obesity in BMI (< 18.5, 18.5–23.0, 23.0–27.5, ≥ 27.5 kg/m2, respectively). Subjects were also divided into hyperuricemia and normal SUA groups.ResultsThe sample included 661 unrelated Chinese. The mean age was 93.52 ± 3.29 years (range 90–108 years). The mean level of BMI was 19.16 ± 3.47 kg/m2 and mean SUA was 318.72 ± 87.01. Compared to individuals without hyperuricemia, high level of SUA was associated with a higher level of BMI in both genders (p < 0.001). According to the both BMI classification criteria, the group with higher BMI had higher level of SUA (p < 0.001). Pearson correlation showed that SUA was significantly correlated with BMI (with coefficients r = 0.235, 0.140, in men and women, respectively). Unadjusted and adjusted multiple logistic regressions showed that odds ratios for hyperuricemia were associated with BMI according to quartile of BMI.ConclusionsWe found that among long-lived Chinese subjects, higher levels of SUA may be associated with higher BMI.

► The large sample of the Nonagenarians/Centenarians. ► The association of serum uric acid with body mass index among longevity Chinese. ► Among longevity subjects, higher levels of SUA were still associated with higher BMI.