| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1907314 | Experimental Gerontology | 2007 | 5 Pages |
Abstract
The production of B lymphocytes begins to decline steadily early in adult life and is severely compromised in the elderly. This occurrence has been attributed to intrinsic defects in early hematopoietic progenitors and B cell precursors as well as to microenvironmental changes in aged bone marrow. The aim of this review is to present an overview of B lymphocyte senescence and its underlying causes and to discuss its impact on immune function and leukemogenesis in aged individuals.
Keywords
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Robert A.J. Signer, Encarnacion Montecino-Rodriguez, Kenneth Dorshkind,