| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1923604 | Acta Histochemica | 2012 | 9 Pages |
Abstract
NFY-C, a subunit of the transcription factor NFY, binds to the promoters of several eukaryotic genes, including cell cycle-related genes. RORA is a steroid hormone receptor implicated in a range of important cellular processes. We evaluated the expression of NFY-C and RORA in colorectal adenocarcinomas and normal colonic tissue. NFY-C expression was elevated in adenocarcinomas. Moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease. RORA expression was downregulated in CRC adenocarcinomas compared to normal controls and correlated with time to disease progression. The role of NFY-C and RORA in CRC merits further investigation.
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Authors
Anastasia E. Kottorou, Anna G. Antonacopoulou, Fotinos-Ioannis D. Dimitrakopoulos, Athanasios C. Tsamandas, Chrisoula D. Scopa, Theodore Petsas, Haralabos P. Kalofonos,