| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1925240 | Archives of Biochemistry and Biophysics | 2014 | 14 Pages |
Abstract
- UDP-galactopyranose mutase (UGM) catalyzes the formation of UDP-galactofuranose.
- UGM requires reduced flavin for activity.
- Nucleophilic attack by the flavin initiates ring contraction.
- Redox-mediated conformational changes are important for flavin activation.
- Closing of the active site flaps is modulated by substrate binding.
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Authors
John J. Tanner, Leonardo Boechi, J. Andrew McCammon, Pablo Sobrado,