| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1925373 | Archives of Biochemistry and Biophysics | 2013 | 8 Pages |
Abstract
⺠Study of L57Q and I61Q cTnC using solution and in silico techniques is presented. ⺠Solution studies indicate both variants decrease the Ca2+ binding affinity to cTnC. ⺠Both variants reduced cTnI affinity to cTnC in Ca2+ saturated states. ⺠MD simulation shows disruption between helices B/C by both cTnC variants. ⺠cTnC (I61Q) formed hydrogen bonds with the residues on the Ca2+ binding loop.
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Authors
Dan Wang, Michelle E. McCully, Zhaoxiong Luo, Jonathan McMichael, An-Yue Tu, Valerie Daggett, Michael Regnier,